Quoter allows you to easily calculate a line item's unit price based on a markup calculation or a margin calculation. Of course, you can also manually set a line item's unit price.
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Default Settings

In Settings > General set your default price modifier so that you can easily view and revise live item pricing based on margin or markup, depending on your preference.

Note: changing the default setting only impacts newly created Quotes. Existing Quotes will default to use the margin/markup based on what the toggle was set to when they were created.